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Vaccine Detail
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Listeria monocytogenes actA mutant vaccine |
| Vaccine Information |
- Vaccine Name: Listeria monocytogenes actA mutant vaccine
- Target Pathogen: Listeria monocytogenes
- Target Disease: Listeriosis
- Vaccine Ontology ID: VO_0002776
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- actA
gene engineering:
- Type: Gene mutation
- Description: This actA mutant is from Listeria monocytogenes (Darji et al., 2003).
- Detailed Gene Information: Click Here.
- Immunization Route: Intravenous injection (i.v.)
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| Host Response |
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Mouse Response
- Persistence: An actA mutant is attenuated in mice (Darji et al., 2003).
- Efficacy: An actA mutant induces significant protection in mice from challenge with wild type L. monocytogenes (Darji et al., 2003).
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| References |
Darji et al., 2003: Darji A, Mohamed W, Domann E, Chakraborty T. Induction of immune responses by attenuated isogenic mutant strains of Listeria monocytogenes. Vaccine. 2003; 21 Suppl 2; S102-109. [PubMed: 12763691].
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