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Vaccine Detail

Mycobacterium tuberculosis lysA/secA2 mutant vaccine

Vaccine Information

Vaccine Name: Mycobacterium tuberculosis lysA/secA2 mutant vaccine
Target Pathogen: Mycobacterium tuberculosis
Target Disease: Tuberculosis
Vaccine Ontology ID: VO_0002783
Type: Live, attenuated vaccine
Status: Research
Host Species as Laboratory Animal Model: Mouse
lysA gene engineering:
- Type: Gene mutation
- Description: This lysA/secA2 mutant is from Mycobacterium tuberculosis (Hinchey et al., 2011).
- Detailed Gene Information: Click Here.
SecA2 gene engineering:
- Type: Gene mutation
- Description: This lysA/secA2 mutant is from Mycobacterium tuberculosis (Hinchey et al., 2011).
- Detailed Gene Information: Click Here.
Immunization Route: subcutaneous injection

Host Response

Mouse Response

Persistence: A lysA/secA2 mutant is highly attenuated in mice (Hinchey et al., 2011).
Efficacy: A lysA/secA2 mutant induces significant protection in mice from challenge with wild type M. tuberculosis (Hinchey et al., 2011).
Information about this animal model: Mouse Model for TB research

References

Hinchey et al., 2011: Hinchey J, Jeon BY, Alley H, Chen B, Goldberg M, Derrick S, Morris S, Jacobs WR Jr, Porcelli SA, Lee S. Lysine auxotrophy combined with deletion of the SecA2 gene results in a safe and highly immunogenic candidate live attenuated vaccine for tuberculosis. PloS one. 2011; 6(1); e15857. [PubMed: 21264335].