• Vaccine Name: Mycobacterium tuberculosis leuD mutant vaccine
• Target Pathogen: Mycobacterium tuberculosis
• Target Disease: Tuberculosis
• Vaccine Ontology ID: VO_0002782
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• leuD gene engineering:
  • Type: Gene mutation
  • Description: This leuD mutant is from Mycobacterium tuberculosis (Hondalus et al., 2000).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intravenous injection (i.v.)

Mouse Response

• Persistence: A leuD mutant is attenuated in mice (Hondalus et al., 2000).
• Efficacy: A leuD mutant induces significant protection in mice from challenge with wild type M. tuberculosis (Hondalus et al., 2000).
• Information about this animal model: Mouse Model for TB research