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leuD
Gene Name	leuD
Sequence Strain (Species/Organism)	Mycobacterium tuberculosis H37Rv
NCBI Gene ID	888225
NCBI Protein GI	15610124
Locus Tag	Rv2987c
Genbank Accession	BX842581
Protein Accession	NP_217503
3D structure: PDB ID	3H5J
Taxonomy ID	83332
Gene Starting Position	3344032
Gene Ending Position	3344628
Gene Strand (Orientation)	-
Protein Name	isopropylmalate isomerase small subunit
Protein pI	4.89
Protein Weight	20390.6
Protein Length	198
Protein Note	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
DNA Sequence	>gi\|57116681:3344032-3344628 Mycobacterium tuberculosis H37Rv, complete genome CTCAGGGGGCGGGTAGAGTGCGCGGTTTCCAGTACGCGCACGCACCCTCAAAGGCCTCGATCTCGTCGAG TTTCCGCAGCGTAAGGGCTATATCGTCGAGACCTTCAAGCAGCCGCCACGCCGAGTGGTCGTCAATCTTG AACGGCAGCACCACTGTTGCTGCGGTGATAATTCGATCTTGAAGATTGGCAGTGATTTCCAGGCCCGGAC TCTGCTCAATGAGCTTCCACAGGAGTTCCACATCGTCTTGGGCAACCTCGGCCGCCAGCAGCCCGGCCTT GCCCGCGTTGCCGCGGAAAATGTCACCAAATCGGGATGAGATAACCACCCGGAATCCGTAGTCCATGAGC GCCCAGACCGCATGCTCTCGCGAGGATCCGGTGCCGAAATCGGGCCCGGCAACCAGGACCGAACCCCGGT CAAAGGGACTGAGGTTTAGCACGAATGCAGGATCCGACCGCCAACCCGCGAACAAGCCGTCCTCGAAACC GGTTCGGGTGACCCGCTTCAGAAAGACCGCGGGAATGATCTGATCGGTGTCGACATTGGACCGCCGCAAC GGCACGCCAATACCAGAGTGGGTGTGAAAGGCTTCCA
Protein Sequence	>gi\|15610124\|ref\|NP_217503.1\| isopropylmalate isomerase small subunit [Mycobacterium tuberculosis H37Rv] MEAFHTHSGIGVPLRRSNVDTDQIIPAVFLKRVTRTGFEDGLFAGWRSDPAFVLNLSPFDRGSVLVAGPD FGTGSSREHAVWALMDYGFRVVISSRFGDIFRGNAGKAGLLAAEVAQDDVELLWKLIEQSPGLEITANLQ DRIITAATVVLPFKIDDHSAWRLLEGLDDIALTLRKLDEIEAFEGACAYWKPRTLPAP
Molecule Role	Virmugen
Molecule Role Annotation	Deletion of leuD gene was shown to be highly attenuated. Immunocompetent BALB/c mice vaccinated with the DleuD auxotroph were protected as well as BCG in terms of survival following an intravenous or aerosol challenge with virulent M. tuberculosis (Hondalus et al., 2000).
Related Vaccines(s)	Mycobacterium tuberculosis leuD mutant vaccine
References

leuD