• Vaccine Name: Mycobacterium tuberculosis drrC mutant vaccine
• Target Pathogen: Mycobacterium tuberculosis
• Target Disease: Tuberculosis
• Vaccine Ontology ID: VO_0002780
• Type: Live, attenuated vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• drrC gene engineering:
  • Type: Gene mutation
  • Description: This drrC mutant is from Mycobacterium tuberculosis (Pinto et al., 2004).
  • Detailed Gene Information: Click Here.
• Immunization Route: Intravenous injection (i.v.)

Mouse Response

• Persistence: A drrC mutant is highly attenuated in mice (Pinto et al., 2004).
• Efficacy: A drrC mutant induces significant protection in mice from challenge with wild type M. tuberculosis (Pinto et al., 2004).
• Host Ifng (Interferon gamma) response
  • Description: The drrC− strain was able to induce splenic anti–M. tuberculosis IFN-γ–secreting T cells responsive to CFP in mice to a level equal to that induced by M. tuberculosis infection and much greater than the amount induced by BCG and control mice. The drrC− mutant was also able to generate high numbers of IFN-γ–secreting cells that recognize the M. tuberculosis ESAT-6 antigen, which BCG and control mice could not do. IFN-gamma levels in both cases were comparable to levels induced by the wild type. This effect began 4 weeks after infection and was sustained long-term (24 weeks after infection) (Pinto et al., 2004).
  • Detailed Gene Information: Click Here.
• Information about this animal model: Mouse Model for TB research