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drrC
Gene Name	drrC
Sequence Strain (Species/Organism)	Mycobacterium tuberculosis H37Rv
NCBI Gene ID	888491
NCBI Protein GI	15610075
Locus Tag	Rv2938
Genbank Accession	BX842581
Protein Accession	NP_217454
Taxonomy ID	83332
Gene Starting Position	3274071
Gene Ending Position	3274901
Gene Strand (Orientation)	?
Protein Name	daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC
Protein pI	10.46
Protein Weight	26320.25
Protein Length	276
Protein Note	Rv2938, (MTCY19H9.06), len: 276 aa. Probable drrC, daunorubicin-DIM-transport integral membrane protein ABC transporter, probably involved in daunorubicin resistance and phthiocerol dimycocerosate transport (see citations below), equivalent to Q9CB71\|ML2350 PROBABLE ANTIBIOTIC RESISTANCE MEMBRANE PROTEIN from Mycobacterium leprae (276 aa), FASTA scores: opt: 1434, E(): 1.2e-81, (79.0% identity in 276 aa overlap); and Q49941\|DRRC\|L518_F3_76 PUTATIVE DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Mycobacterium leprae (244 aa), FASTA scores: opt: 1194, E(): 8.3e-67, (76.85% identity in 242 aa overlap). Also similar to others e.g. Q9XCF9 DRRC PROTEIN from Mycobacterium avium (263 aa), FASTA scores: opt: 538, E(): 3.7e-26, (32.65% identity in 251 aa overlap); Q9S6H3 DAUNORUBICIN RESISTANCE PROTEIN C from Mycobacterium avium (263 aa), FASTA scores: opt: 533, E(): 7.6e-26, (32.25% identity in 251 aa overlap); P32011\|DRRB_STRPE DAUNORUBICIN RESISTANCE TRANSMEMBRANE PROTEIN from Streptomyces peucetius (283 aa), FASTA scores: opt: 276, E(): 6.6e-10, (21.07% identity in 261 aa overlap); etc. Note that Rv2938\|drrC belongs to the transcriptional unit Rv2930\|fadD26-Rv2939\|papA5 (proven experimentaly).
DNA Sequence	>gi\|57116681:3274071-3274901 Mycobacterium tuberculosis H37Rv, complete genome CATGATCACGACGACAAGTCAGGAAATCGAGCTTGCACCCACACGTTTGCCAGGCTCGCAAAACGCTGCT CGGCTGTTCGTTGCGCAGACCCTTTTGCAGACCAACCGGTTGCTAACTCGATGGGCACGTGACTATATCA CCGTTATCGGAGCGATCGTGTTACCGATTCTCTTCATGGTGGTGTTGAACATTGTGCTAGGTAACCTAGC TTATGTCGTAACCCACGACAGCGGGCTCTACAGCATTGTTCCGCTGATCGCACTCGGCGCCGCGATCACT GGGTCAACTTTTGTCGCGATCGACCTGATGCGCGAGCGCTCCTTCGGACTGCTTGCCCGACTGTGGGTGC TGCCCGTGCACCGAGCATCGGGCCTGATCTCTCGAATCCTGGCAAACGCGATTCGGACTCTGGTCACCAC TTTAGTGATGCTAGGTACTGGGGTGGTATTGGGTTTCCGGTTTCGACAAGGCCTGATCCCGAGCCTCATG TGGATTAGTGTCCCGGTGATACTGGGCATCGCAATCGCGGCTATGGTCACTACCGTCGCGCTTTACACAG CACAAACCGTTGTTGTCGAAGGCGTTGAGCTGGTGCAAGCAATCGCGATCTTCTTCTCCACGGGTTTGGT GCCGCTCAACTCGTATCCAGGCTGGATTCAGCCGTTCGTCGCCCATCAGCCGGTGAGCTACGCCATCGCG GCGATGCGCGGTTTTGCAATGGGTGGTCCGGTCCTCTCTCCGATGATCGGGATGCTGGTGTGGACCGCGG GTATCTGCGTCGTATGCGCCGTACCCTTGGCCATTGGCTACCGACGGGCCAGCACGCATTG
Protein Sequence	>gi\|15610075\|ref\|NP_217454.1\| daunorubicin-DIM-transport integral membrane protein ABC transporter DrrC [Mycobacterium tuberculosis H37Rv] MITTTSQEIELAPTRLPGSQNAARLFVAQTLLQTNRLLTRWARDYITVIGAIVLPILFMVVLNIVLGNLA YVVTHDSGLYSIVPLIALGAAITGSTFVAIDLMRERSFGLLARLWVLPVHRASGLISRILANAIRTLVTT LVMLGTGVVLGFRFRQGLIPSLMWISVPVILGIAIAAMVTTVALYTAQTVVVEGVELVQAIAIFFSTGLV PLNSYPGWIQPFVAHQPVSYAIAAMRGFAMGGPVLSPMIGMLVWTAGICVVCAVPLAIGYRRASTH
Molecule Role	Virmugen
Molecule Role Annotation	A drrC mutant is highly attenuated in mice and induces significant protection from challenge with wild type M. tuberculosis (Pinto et al., 2004).
Related Vaccines(s)	Mycobacterium tuberculosis drrC mutant vaccine
References

drrC