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Vaccine Detail

Salmonella Gallinarum cbiA/cobS mutant vaccine
Vaccine Information
  • Vaccine Name: Salmonella Gallinarum cbiA/cobS mutant vaccine
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Type: Live, attenuated vaccine
  • Status: Research
  • Host Species as Laboratory Animal Model: Chickens
  • cbiA gene engineering:
    • Type: Gene mutation
    • Description: This cbiA/cobS mutant is from Salmonella Gallinarum (Penha et al., 2010).
    • Detailed Gene Information: Click Here.
  • cobS gene engineering:
    • Type: Gene mutation
    • Description: This cbiA/cobS mutant is from Salmonella Gallinarum (Penha et al., 2010).
    • Detailed Gene Information: Click Here.
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Chicken Response

  • Persistence: A cbiA/cobS mutant is attenuated in chickens (Penha et al., 2010).
  • Efficacy: A cbiA/cobS mutant induces significant protection in chickens from challenge with wild type S. Gallinarum (Penha et al., 2010).
References
Penha et al., 2010: Penha Filho RA, de Paiva JB, da Silva MD, de Almeida AM, Berchieri A Jr. Control of Salmonella Enteritidis and Salmonella Gallinarum in birds by using live vaccine candidate containing attenuated Salmonella Gallinarum mutant strain. Vaccine. 2010; 28(16); 2853-2859. [PubMed: 20153354].