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Vaccine Detail
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Salmonella typhi aroA mutant vaccine |
| Vaccine Information |
- Vaccine Name: Salmonella typhi aroA mutant vaccine
- Target Pathogen: Salmonella spp.
- Target Disease: Salmonellosis
- Vaccine Ontology ID: VO_0002863
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- aroA
gene engineering:
- Type: Gene mutation
- Description: This aroA was mutated from Salmonella typhi strain Ty2 (Dougan et al., 1987).
- Detailed Gene Information: Click Here.
- Immunization Route: Intraperitoneal injection (i.p.)
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| Host Response |
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Mouse Response
- Persistence: An aroA mutant is attenuated in mice (Dougan et al., 1987).
- Efficacy: An aroA mutant induced significant protection in mice from challenge with wild type S. typhi Ty2 (Dougan et al., 1987).
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| References |
Dougan et al., 1987: Dougan G, Maskell D, Pickard D, Hormaeche C. Isolation of stable aroA mutants of Salmonella typhi Ty2: properties and preliminary characterisation in mice. Molecular & general genetics : MGG. 1987; 207(2-3); 402-405. [PubMed: 3039297].
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