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Vaccine Detail
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Yersinia pestis smpB/ssrA mutant vaccine |
| Vaccine Information |
- Vaccine Name: Yersinia pestis smpB/ssrA mutant vaccine
- Target Pathogen: Yersinia pestis
- Target Disease: Plague
- Type: Live, attenuated vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- smpB
gene engineering:
- Type: Gene mutation
- Description: This smpB/ssrA mutant is from Yersinia pestis (Okan et al., 2010).
- Detailed Gene Information: Click Here.
- ssrA
gene engineering:
- Type: Gene mutation
- Description: This smpB/ssrA mutant is from Yersinia pestis (Okan et al., 2010).
- Detailed Gene Information: Click Here.
- Immunization Route: intranasal immunization
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| Host Response |
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Mouse Response
- Persistence: An smpB/ssrA mutant is attenuated in mice (Okan et al., 2010).
- Efficacy: An smpB/ssrA mutant induces significant protection from challenge with wild type Y. pestis in mice (Okan et al., 2010).
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| References |
Okan et al., 2010: Okan NA, Mena P, Benach JL, Bliska JB, Karzai AW. The smpB-ssrA mutant of Yersinia pestis functions as a live attenuated vaccine to protect mice against pulmonary plague infection. Infection and immunity. 2010; 78(3); 1284-1293. [PubMed: 20065026].
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