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smpB

Gene Name smpB
Sequence Strain (Species/Organism) Yersinia pestis CO92
NCBI Gene ID 1173949
NCBI Protein GI 218928269
Locus Tag YPO1101
Genbank Accession AL590842
Protein Accession YP_002346144
Taxonomy ID 214092
Gene Starting Position 1245999
Gene Ending Position 1246481
Gene Strand (Orientation) -
Protein Name SsrA-binding protein
Protein pI 10.62
Protein Weight 17315.72
Protein Length 160
Protein Note Also known as smqBbinds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
DNA Sequence 
>gi|16120353:1245999-1246481 Yersinia pestis CO92 chromosome, complete genome
CTTAACGATTTGCGTGCTTCATGATGCGCGCTTTGTCTAACTTCCACTCACGATCTCTAATATCATCGCG
CTTGTCGTTATCTTTTTTACCTTTTGCTACGCCGATTTTAACTTTCACCCAGGCATTTTTCCAATACATG
GAGAGAGCGACAACCGTGTAGCCTTCTCGGTTCACTCGGCCAAACAAGGAATCCAGTTCGCGTTTGTTCA
ACAGCAGTTTACGGGTACGCATAGGCTCGCAAACAACATGAGTCGACGCAACGTTCAACGGCGTAATTGT
GGCCCCAAACAGGAATGCCTCACCGTTTTTAAACATTACGTAGCTGTCACTGATATTTGCTTTGCCTGCA
CGCAGTGATTTTACTTCCCAACCTTGCAGTGCAAGCCCAGCTTCGAACTCTTCTTCAATGAAGTATTCGT
GACGGGCTCGTTTATTTTGCGCAATGGTTGCGGAACCGGGTTTGTATGCTTTTTTCTTTGTCA
Protein Sequence 
>gi|218928269|ref|YP_002346144.1| SsrA-binding protein [Yersinia pestis CO92]
MTKKKAYKPGSATIAQNKRARHEYFIEEEFEAGLALQGWEVKSLRAGKANISDSYVMFKNGEAFLFGATI
TPLNVASTHVVCEPMRTRKLLLNKRELDSLFGRVNREGYTVVALSMYWKNAWVKVKIGVAKGKKDNDKRD
DIRDREWKLDKARIMKHANR
Molecule Role Virmugen
Molecule Role Annotation An smpB mutant, in combination with an ssrA mutation, is attenuated in mice and induces significant protection from challenge with wild type Y. pestis (Okan et al., 2010).
Related Vaccines(s) Yersinia pestis smpB/ssrA mutant vaccine
References