• Vaccine Name: rgp120 HIV Vaccine with immunoliposomes
• Target Pathogen: Human Immunodeficiency Virus
• Target Disease: Acquired Immunodeficiency Syndrome (AIDS)
• Vaccine Ontology ID: VO_0004264
• Type: Subunit vaccine
• Status: Research
• Antigen: rgp120 (Ozpolat et al., 1998).
• Adjuvant: immunoliposomes containing antibodies to costimulatory molecules
  • Adjuvant name: immunoliposomes containing antibodies to costimulatory molecules
  • VO adjuvant ID: VO_0001343
• Immunization Route: subcutaneous injection

Mouse Response

• Host Strain: C3H/HeN
• Vaccination Protocol: Groups of five mice were immunized subcutaneously three times at 14-day intervals. The immunoliposomes were suspended in PBS and each mouse received 0.1 ml per injection. Each injection contained 380 μg of PC, 193 μg of CH, 10 pg of PE-B, 2.0 μg of MAb, and 10 μg of rgpl20 (Ozpolat et al., 1998).
• Immune Response: Mice vaccinated with immunoliposomes were found to have a strong delayed-type hypersensitivity (DTH) response to the weakly immunogenic gp120 that was dependent on the presence of the MAbs. However, this vaccination protocol did not induce humoral immunity (Ozpolat et al., 1998).