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Vaccine Detail
Cancer Subunit GV1001 Protein Vaccine |
Vaccine Information |
- Vaccine Ontology ID: VO_0011507
- Type: Subunit vaccine
- Status: Clinical trial
- TERT
gene engineering:
- Type: Recombinant protein preparation
- Detailed Gene Information: Click Here.
- Adjuvant:
- Immunization Route: Intradermal injection (i.d.)
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Host Response |
Human Response
- Vaccination Protocol: Forty-eight treatment naive patients with non-resectable, histologially confirmed adenocarcinoma of the pancreas were enrolled in the study (September 2000–March 2003). he vaccine was administered by intradermal (i.d.) injection in the right para-umbilical area following the schedule; three injections in week 1and one weekly injection in weeks 2, 3, 4, 6, and 10. The three different doses of vaccine administered were; low dose: 60 nmole (112 μg) GV1001 in 0.10 ml saline, intermediate dose: 300 nmole (560 μg) GV1001 in 0.125 ml saline, and high dose: 1.0 μmole (1.87 mg) GV1001 in 0.20 ml saline. From 5 to 15 min before each vaccine injection, 30 μg granulocyte–macrophage colony-stimulating factor in 0.10 ml saline was injected i.d. at the vaccination site (Bernhardt et al., 2006).
- Immune Response: Overall, a vaccine related immune response was detected in 63% of the evaluable study population (Bernhardt et al., 2006).
- Efficacy: Median survival for the intermediate dose-group was 8.6 months, significantly longer for the low- (P = 0.006) and high-dose groups (P = 0.05). One-year survival for the evaluable patients in the intermediate dose group was 25% (Bernhardt et al., 2006).
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References |
Bernhardt et al., 2006: Bernhardt SL, Gjertsen MK, Trachsel S, Møller M, Eriksen JA, Meo M, Buanes T, Gaudernack G. Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: A dose escalating phase I/II study. British journal of cancer. 2006; 95(11); 1474-1482. [PubMed: 17060934].
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