VIOLIN: Vaccine Investigation and Online Information Network

ler
Gene Name	ler
Sequence Strain (Species/Organism)	Escherichia coli O157:H7 str. TW14359
NCBI Gene ID	8219269
NCBI Protein GI	254795663
Locus Tag	ECSP_4703
Genbank Accession	CP001368
Protein Accession	YP_003080500
Taxonomy ID	544404
Gene Starting Position	4678930
Gene Ending Position	4679301
Gene Strand (Orientation)	-
Protein Name	enterocyte effacement (LEE)-encoded regulator
Protein pI	4.97
Protein Weight	13635.36
Protein Length	123
DNA Sequence	>gi\|254791136:4678930-4679301 Escherichia coli O157:H7 str. TW14359, complete genome GTTAAATATTTTTCAGCGGTATTATTTCTTCTTCAGTGTCCTTCACAAGAAAATCTTCTTTCTTCATTCC ATTCAACAGTGCTTCTTTAAGCCAGCGTGGCTGTCGGCCTACGCCCGACCAGGTCTGCCCTTCTTCATTG CGGTAGTAAACACCTTTCGATGAGTTCCGGCGAGCGAGTCCATCATCAGGCACATTAGTATATCCCAGCT CTTGTAAGGTTATATTGTAATAAGTAATCTGCTTCTGAATCGACTCAATTACACTTTGAACTTCCTGCTC TCGCAGTCGCTTTGCTTCCTGCTGTAGAACTGCAATTTGCTCTATAAGCTGAATGTATGGACTTGTTGTA TGTGAATTATTTTCCATATTCA
Protein Sequence	>gi\|254795663\|ref\|YP_003080500.1\| locus of enterocyte effacement (LEE)-encoded regulator [Escherichia coli O157:H7 str. TW14359] MNMENNSHTTSPYIQLIEQIAVLQQEAKRLREQEVQSVIESIQKQITYYNITLQELGYTNVPDDGLARRN SSKGVYYRNEEGQTWSGVGRQPRWLKEALLNGMKKEDFLVKDTEEEIIPLKNI
Molecule Role	Virmugen
Molecule Role Annotation	A ler deletion mutant derived from wild-type EHEC O157:H7 86-24 was constructed by use of suicide vector pCVD442. Following challenge of 7-day-old suckling mice with O157:H7 EDL933, 75.2% born to group B mothers (immunized with F25) sur- vived, as did 83.0% born to group C mothers (immunized with F105). The surviving suckling mice consistently gained body weight. Only 16.8% of sucking mice born to control group mice survived the challenge (Liu et al., 2009).
Related Vaccines(s)	Escherichia coli ler mutant vaccine
References

ler