VIOLIN: Vaccine Investigation and Online Information Network

aroC
Gene Name	aroC
Sequence Strain (Species/Organism)	Burkholderia pseudomallei 1106a
NCBI Gene ID	4899749
NCBI Protein GI	126453136
Locus Tag	BURPS1106A_1713
Genbank Accession	CP000572
Protein Accession	YP_001065984
Taxonomy ID	357348
Chromosome No	I
Gene Starting Position	1672513
Gene Ending Position	1673622
Gene Strand (Orientation)	+
Protein Name	chorismate synthase
Protein pI	6.35
Protein Weight	36184.83
Protein Length	369
Protein Note	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
DNA Sequence	>gi\|126451443:1672513-1673622 Burkholderia pseudomallei 1106a chromosome I, complete genome TATGTCCGGCAACACCCTCGGCACGCTTTTCACTGTCACGACCTTCGGCGAATCGCACGGCCCCGCGATC GGCTGCGTGATCGACGGCTGCCCGCCGGGCATGGCGCTCACGGAAGCCGACGTCCAGCTCGAGCTCGACC GCCGCAAGCCCGGCACGTCGCGCCACGTCACGCAGCGTCAGGAGCCCGACCAGGTCGAGATCCTGTCCGG CGTGTTCGAGGGCGTGACGACCGGCGCGCCGATCGCGCTCCTGATCCGCAACACCGACCAGCGCAGCAAG GACTACGGCAACATCGCCGAGACGTTCCGCCCGGGCCATGCCGATTACACCTACTGGCAAAAGTACGGCG TGCGCGACTATCGCGGCGGCGGCCGCTCGTCCGCGCGGCTGACGGCGCCCGTCGTCGGCGCCGGCGCGAT CGCGAAGAAGTGGCTGCGCGAGCGCTTCGGCGTCGAGGTGCGCGGCTACATGAGCGCGCTCGGCGAAATC GAGATCCCGTTCGTCGACTGGTCGCACGTGCGCGAGAACCCGTTCTTCGCGCCGAACGCCGACATCGTGC CGCAACTCGAGGGCTACATGGACGCGCTGCGCAAGGACGGCGATTCGATCGGCGCGCGCATCGATGTCGT CGCGTCGGGCGTGCCGGTCGGCTGGGGCGAGCCGCTGTTCGACCGGCTCGACGCCGACATCGCGCACGCG ATGATGGGGATCAACGCGGTGAAGGGCGTCGAGATCGGCGCGGGTTTCGCGAGCGTCGCGCAGCGCGGTT CGGTGCACGGCGACGAGCTGACGCCGGACGGCTTCGTCGGCAATCACGCGGGCGGCGTGCTCGGCGGCAT CTCGACGGGGCAGGACATCACGGTGTCGATCGCGATCAAGCCGACGTCGAGCATTCGCACGCCGCGCCGC TCGATCACGCGGGCGGGCGAACCCGCCGTCGTCGAGACGTTCGGCCGCCACGACCCGTGCGTCGGGATTC GCGCGACGCCGATCGCCGAATCGATGCTCGCGCTCGTGCTGATCGATCACGCGCTGCGGCACCGCGCGCA GTGCGGCGACGTGTCGAGCGCGACGCCGAGGATCGCCGCGCGCGCGCCGGACGCGCAATG
Protein Sequence	>gi\|126453136\|ref\|YP_001065984.1\| chorismate synthase [Burkholderia pseudomallei 1106a] MSGNTLGTLFTVTTFGESHGPAIGCVIDGCPPGMALTEADVQLELDRRKPGTSRHVTQRQEPDQVEILSG VFEGVTTGAPIALLIRNTDQRSKDYGNIAETFRPGHADYTYWQKYGVRDYRGGGRSSARLTAPVVGAGAI AKKWLRERFGVEVRGYMSALGEIEIPFVDWSHVRENPFFAPNADIVPQLEGYMDALRKDGDSIGARIDVV ASGVPVGWGEPLFDRLDADIAHAMMGINAVKGVEIGAGFASVAQRGSVHGDELTPDGFVGNHAGGVLGGI STGQDITVSIAIKPTSSIRTPRRSITRAGEPAVVETFGRHDPCVGIRATPIAESMLALVLIDHALRHRAQ CGDVSSATPRIAARAPDAQ
Molecule Role	Virmugen
Molecule Role Annotation	The aroC deletion in the resultant mutant, designated A2ΔaroC, was confirmed by PCR, Southern hybridization and failure of the mutant to grow in a defined medium without aromatic compounds. The constructed unmarked aroC mutant of B. pseudomallei is attenuated in both BALB/c and C57Bl/6 mice and is able to confer significant protection in C57Bl/6 mice (Srilunchang et al., 2009).
Related Vaccines(s)	Burkholderia pseudomallei aroC deletion mutant vaccine
References

aroC