VIOLIN: Vaccine Investigation and Online Information Network

G2
Gene Name	G2
Sequence Strain (Species/Organism)	Trypanosoma cruzi
VO ID	VO_0011299
NCBI Gene ID	3543901
NCBI Protein GI	71424025
Genbank Accession	AAHK01000586
Protein Accession	XP_812654
Taxonomy ID	5693
Chromosome No	Unknown
Gene Starting Position	46754
Gene Ending Position	47725
Gene Strand (Orientation)	+
Protein Name	protein G2
Protein pI	7.16
Protein Weight	33715.38
Protein Length	323
DNA Sequence	>NW_001849278.1:46754-47725 Trypanosoma cruzi strain CL Brener 1047053517025 genomic scaffold, whole genome shotgun sequence GATGGCGAGGCGAGCGGCACTGCGATGGTGGCCGGCGTGCGGGCCATTGGATTTATTTTTGAAAAACGAG GAAGTCAAGAATCCTAGCTTGTGTGTGCATAAGAATGATTTTGGTCAAATGGTGTTGAGTGGCATGGGAG AATTACATCTTGAAATTGTCATGTCCCTCTTGGAGCACGATTATAAACTAAAGTGTCGACTACTACGTGC CATCGTAGAATATCGTGAGGTAGTCCTTGAGGCAGTGGAGCTCCTGCATGGTATTGGGATGTACAATGAG CTCCCATACGTTGAGTGTTCGCTGCGACTCCAGCCACTACTTGAGGAAGATGGCTTCTGCGATCCAGTTC AATATTGTTCCTTTGTTCTTGACGAGACGTTGACGGAGAAATATCTTGCTGGAGCCGCTGGTTCCCGTAA TGATCGACGTCGCCGCATGGAGGATCACCACCGTAATGTGAAGGAGGAACTACGAATAAACACCGATGTT TTTTCTCGCGCAGTCACCGATTGCTCTCACATGGGTCCCCTTGCCGGTTTGCCTCTCCACGGCGTGCGGG TCGCTTTGCTGGAATTCAAAAAGCTTGGTGGCACGCAGCTGTCGGAGGGCCCTCTACAGCAGGCCGCTCG TTCTCTTGTATTGGAGCTGTTTCGCTCCGTTTCCAAGGCCAATCTTGCCACGATGGAGCCAATGATGGAG GTGGAGGTGCACCTCTCGGAGGCAGCCTACATTGGTGGTGTTGTGAGCTCTCTGAGCGAGCGTAAGGCCA TTGCGGTGGACATTCAAGATGATGGGAGGTCGGTGAAAGCAATCGTCCCGATGCGAAACATAGTTCGCTA CACAATGGAACTTTGGAAGGCGGTGAAGGGGCATGCCAGTCTGTACGCACGCTTGCACCACTACCGTGTA ATTGAAGAAAAGGCTGTCCTCTCGCGAATCATGAAGAATTTGGGCATTTACGAAGGCCATTG
Protein Sequence	>XP_812654.1 elongation factor G2-like protein, putative [Trypanosoma cruzi] MARRAALRWWPACGPLDLFLKNEEVKNPSLCVHKNDFGQMVLSGMGELHLEIVMSLLEHDYKLKCRLLRA IVEYREVVLEAVELLHGIGMYNELPYVECSLRLQPLLEEDGFCDPVQYCSFVLDETLTEKYLAGAAGSRN DRRRRMEDHHRNVKEELRINTDVFSRAVTDCSHMGPLAGLPLHGVRVALLEFKKLGGTQLSEGPLQQAAR SLVLELFRSVSKANLATMEPMMEVEVHLSEAAYIGGVVSSLSERKAIAVDIQDDGRSVKAIVPMRNIVRY TMELWKAVKGHASLYARLHHYRVIEEKAVLSRIMKNLGIYEGH
Molecule Role	Protective antigen
Molecule Role Annotation	The vaccine efficacy of a putative candidate antigen against T. cruzi infection and disease in a mouse model. C57BL/6 mice vaccinated with a T. cruzi G2-encoding plasmid and cytokine (interleukin-12 and granulocyte-macrophage colony-stimulating factor) expression plasmids elicited a strong Th1-type antibody response dominated by immunoglobulin G2b (IgG2b)/IgG1 isotypes. The dominant IgG2b/IgG1 antibody response was maintained after a challenge infection and was associated with 50% control of the acute-phase tissue parasite burden and an almost undetectable level of tissue parasites during the chronic phase, as determined by a sensitive T. cruzi 18S rRNA gene-specific real-time PCR approach (Bhatia and Garg, 2008).
Related Vaccines(s)	T. cruzi DNA prime/Protein-boost vaccine encoding TcG2 and TcG4 , T. cruzi DNA Vaccine encoding G2 Protein , T. cruzi DNA-prime/MVA-boost vaccine encoding TcG2 and TcG4 , T. cruzi vaccine encoding TcG2 and TcG4 , T. cruzi Vaccine TcVac2 , T. cruzi Vaccine TcVac3 encoding TcG2 and TcG4 , T. cruzi Vaccine TcVac4
References

G2