VIOLIN: Vaccine Investigation and Online Information Network

TS
Gene Name	TS
Sequence Strain (Species/Organism)	Trypanosoma cruzi
VO ID	VO_0011294
NCBI Protein GI	258547365
Other Database IDs	CDD:271234 CDD:304605
Taxonomy ID	5693
Gene Strand (Orientation)	?
Protein Name	trans-sialidase
Protein pI	7.26
Protein Weight	32935.95
Protein Length	385
Protein Note	Non-viral sialidases; cd15482
Protein Sequence	>ACV74334.1 trans-sialidase, partial [Trypanosoma cruzi] THPLNFKGRWLRDRLNLWLTDNQRIYNVGQVSIGDENSAYSSVLYKDDKLYCLHEINTNEVYSLVFARLV GELRIIKSVLQSWKNWDSHLSSICTPADPAASSSERGCGPAVTTVGLVGFLSGNASQNVWEDAYRCVNAS TANAERVPNGLKFAGVGGGALWPVSQQGQNQRYRFANHAFTLVASVTIHEVPSVASPLLGASLDSSGGKK LLGLSYDEKHQWQPIYGSTPVTPTGSWETGKRYHVVLTMANKMGSVYIDGEPLEGSGQTVAPDERTPDIS HFYVGGYKRSDMPTISHVTVNNVLLYNRQLNAEEIRTLFLSQ
Molecule Role	Protective antigen
Molecule Role Annotation	To develop a vaccine strategy taking advantage of activated CD8(+)T cells,a DNA vaccine, designated pGFP-TSA1, encoding a fusion protein linking GFP to a single CTL epitope of TSA1(TS), a leading candidate for vaccine against T. cruzi was constructed. C57BL/6 mice vaccinated with this plasmid showed suppressed parasitemia and prolonged survival. Vaccination with pGFP-TSA1 enhanced epitope-specific cytotoxicity and IFN-gamma secretion by CD8(+)T cells (Chou et al., 2008).
Related Vaccines(s)	T. cruzi DNA Vaccine pGFP-TSA1 , T. cruzi DNA vaccine pTS encoding T. cruzi antigens
References