VIOLIN: Vaccine Investigation and Online Information Network

PSA-2
Gene Name	PSA-2
Sequence Strain (Species/Organism)	Leishmania major
VO ID	VO_0011279
NCBI Gene ID	5649964
NCBI Protein GI	1129058
Other Database IDs	CDD:215061 CDD:275380
Taxonomy ID	5664
Gene Strand (Orientation)	?
Protein Name	surface antigen 2
Protein pI	4.54
Protein Weight	37463.69
Protein Length	441
Protein Note	leucine-rich repeat receptor-like protein kinase; Provisional
Protein Sequence	>AAB38549.1 surface antigen 2 [Leishmania major] MAQCVRRLVLAATLAAAVALLLCTSSAPVARAAGTGDFTAAQRTNTLAVLQAFGRAIPKLGEKWAGNDFC SWEAVLCNAPDVYVSGISPTYAGTLPEMPVNVDYRHVVIKQLDFSEMGPGLSGTLPASWHSMTSLESLSI EKCESISGSVPPEWGSMTSLSVLNLRGTGISGTLPPQWSGMSKARSLQLQDCDLSGSLPSSWSAIPMLAS VSLKGNKFCGCVPDSWDQKAGLVVDIEDKHKGSDCLAAKDCTTTTTKPSATTATTPNLTNFPPTPRTTTE PLTTTSTEAPAEPTTTTEAPAEPTTTATPTNTPTPAPETECEVDGCEVCEGDSAARCARCREDYFLTDEK TCLKHNDGGVAAVSSGVAAAAVVCVAVLFSVGLAA
Molecule Role	Protective antigen
Molecule Role Annotation	Intraperitoneal vaccination of C3H/He mice with PSA-2 with Corynebacterium parvum as an adjuvant resulted in complete protection from lesion development after challenge infection with virulent L. major. Significant protection was also obtained in the genetically susceptible BALB/cH-2k and BALB/c mice (Handman et al., 1995).
Related Vaccines(s)	L. major PSA-2 Protein Vaccine
References