VIOLIN: Vaccine Investigation and Online Information Network

ORF2
Gene Name	ORF2
Sequence Strain (Species/Organism)	Porcine circovirus type 2
VO ID	VO_0011243
NCBI Protein GI	78217439
Other Database IDs	CDD:280582
Taxonomy ID	85708
Gene Strand (Orientation)	?
Protein Name	ORF2
Protein pI	11.34
Protein Weight	26948.82
Protein Length	278
Protein Note	Circovirus capsid protein; pfam02443
Protein Sequence	>ABB36795.1 ORF2 [Porcine circovirus 2] MAYPRRRYRRRRHRPRSHLGQILRRRLWLLHPRHRYRWRRKNGIFNTRLSRTFGYTIKRTTVKTPSWAVD MMRFNINDFLPPGGGSNPRSVPFEYYRIRKVKVEFWPCSPITQGDRGVGSSAVILDDNFVTKATALTYDP YVNYSSRHTITQPFSYHSRYFTPKPVLDSTIDYFQPNNKRNQLWLRLQTAGNVDHVGLGTAFENSIYDQE YNIRVTMYVQFREFNLKDPPLKP
Molecule Role	Protective antigen
Molecule Role Annotation	An open reading frame 2 plasmid (pORF2) and the capsid protein (Cap) of PCV2 were used as DNA and subunit vaccines, respectively. In FCM analysis, although pORF2 and Cap alone showed comparable efficacy in eliciting lymphoproliferative responses and Cap-specific CD4(+) T cells, pORF2 was superior to the Cap protein in triggering CD8(+) T cells. Following virus challenge, real-time PCR and histopathological analysis confirmed that only low viral DNA loads and mild microscopic lesions appeared in pORF2-immunized mice (Shen et al., 2008).
Related Vaccines(s)	PCV2 DNA Vaccine encoding ORF2 Protein , PrV-PCV2-ORF2
References