VIOLIN: Vaccine Investigation and Online Information Network

psaA
Gene Name	psaA
Sequence Strain (Species/Organism)	Streptococcus pneumoniae
VO ID	VO_0011190
NCBI Protein GI	NP_359087
3D structure: PDB ID	1PSZ
Other Database IDs	CDD:238557
Taxonomy ID	171101
Gene Strand (Orientation)	?
Protein Name	ABC transporter substrate-binding protein - manganese transport
Protein pI	5.19
Protein Weight	33579.58
Protein Length	421
Protein Note	Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; cd01137
Protein Sequence	>AAL00298.1 ABC transporter substrate-binding protein - manganese transport [Streptococcus pneumoniae R6] MKKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIADITKNIAGDKIDLHSIVPIGQDPHEYE PLPEDVKKTSEADLIFYNGINLETGGNAWFTKLVENAKKTENKDYFAVSDGVDVIYLEGQNEKGKEDPHA WLNLENGIIFAKNIAKQLSAKDPNNKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKY FSKAYGVPSAYIWEINTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQIFTD SIAEQGKEGDSYYSMMKYNLDKIAEGLAK
Molecule Role	Protective antigen
Molecule Role Annotation	Vaccination with an RASV synthesizing full-length PsaA induced high titers of anti-PsaA antibodies in both systemic (IgG in serum) and mucosal (IgA in vaginal washes, nasal washes, and lung homogenates) sites. BALB/c (haplotype H2(d)) or C57BL/6 (haplotype H2(b)) mice vaccinated either orally or intranasally exhibited a significant reduction in colonization of nasopharyngeal tissues after intranasal challenge with S. pneumoniae strains compared to controls, although protection was not observed with all challenge strains. None of the vaccine constructs provided protection against intraperitoneal challenge with S. pneumoniae strain WU2 (serotype 3) (Wang et al., 2010). The results of colonization experiment showed that compared with the control group, the PepO, PsaA, and combined immunization groups showed a significant reduction in the colonization of Streptococcus pneumoniae (CMCC31693 and CMCC31207) in the nasopharynx and lung (P<0.05).(Zhang et al., 2017)
Related Vaccines(s)	PsaA DNA Vaccine , S. pneumoniae RASV synthesizing PsaA
References

psaA