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spag-1
Gene Name	spag-1
Sequence Strain (Species/Organism)	Theileria annulata
VO ID	VO_0011187
NCBI Protein GI	161885
Other Database IDs	CDD:253298
Taxonomy ID	5874
Gene Strand (Orientation)	?
Protein Name	sporozoite surface antigen
Protein pI	4.77
Protein Weight	83569.63
Protein Length	981
Protein Note	Sporozoite P67 surface antigen; pfam05642
Protein Sequence	>AAA30134.1 sporozoite surface antigen [Theileria annulata] MNIIHFLLTIPAIFVSGADKMPAGESSRTSKPSPLVTLESAVTQPSKDPFKTISALSKATKVWKSAVSVS GDSKTVPTPVSEPMITRSFQEPVSQELEFQSDTEINESGSGSDEDEDDDDDEEEEEDDKSTSSKNGKGSP KAQPGVSSSSTSSASPTSPTTTLSQTGLGPSGSHAQQDPGVGVPGVGVPGVGVPGVGVPGVGVPGVGVPG VGGVPGVGVAPGVGVPGVGVAPGVGVGADSSGLPGSGGLGAGAKAGKGQGSGLQGPGGVGVVPGVGVAAS SSSPGKPPGVGAGVMPGVGVRAQGGVIIGAPGVAGVPGGKPGQPVSQELELKSDTEINESGSSSEGEDDD DEEEEEENKSTSSKGAGGKAGKGQGSVSPGGGSSASQTSPTTTPQSGLASSGSHAQQSPQQDPAPSKPSG GGVPGVGVPGVGVPGVGVPGVGVAPGVGVVPGVGGATTSSSSTTSTSTSTTTTTTTSSGKPSDQGSHGTS PRNAVTRQTDSISGPIPSPGDPRAITGQMGEGERFAVQFLGDFKPKPRRYEGQGTDAVKLKQFIFEEVKS LVQTLINLKLAIANDFVEISEKLKKKNQNYVPKLKLLKGEQFDTKQKVANVLKGFNSLYFVFFMNLNLAK EVNKPEELAEFLWKLNTIPDKVGREFELAIEKTKGSEKKKELEEAFNSIGLGFKIAQYATNDILSSITNS VYSLIKLKNFGDDFVTEVRKSLQMVPHQKNLNGSAFIVKISEIINKKGTEDQDQTSGSGSKGTEGGSLRG QDLTEEEVLKVLDELVKDVSEEHVGIGDLSDPSSRTPNAKPAELGPSLVIQNVPSDPSKVTPTQPSNLPQ VPTTGPGNGTDGTTTGPGGNGEGGKDLKEGEKKEGLFQKIKNKLLGSGFEVASIIIPMTTIIFSIVH
Molecule Role	Protective antigen
Molecule Role Annotation	The trial vaccination of cattle against T. annulata using recombinant sporozoite antigens (SPAG-1 and p67) and/or merozoite antigens (TAMS 1-1 and 1-2). The aim of these trials was to try and enhance the levels of protection induced compared with previous trials. Different approaches were tried. SPAG-1 was expressed as a fusion protein with a His6 tag and then either incorporated into ISCOMs, with or without TAMS 1-1 and 1-2, or administered with RWL, a proprietary saponin-based adjuvant. Cross-protection studies were also performed by immunizing cattle with the T. parva sporozoite antigen, p67, and then challenging with a T. annulata sporozoite stabilate.All the data collected from these two trials indicate that SPAG-1 administered with RWL is better at inducing an effective immune response than SPAG-1 incorporated into ISCOMs, with or without the presence of merozoite antigens (Boulter et al., 1998).
Related Vaccines(s)	T. annulata Subunit SPAG-1 Protein Vaccine
References

spag-1