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D15

Gene Name D15
Sequence Strain (Species/Organism) Haemophilus influenzae 86-028NP
VO ID VO_0011083
NCBI Gene ID 3430379
NCBI Protein GI 68249503
Locus Tag NTHI1084
Genbank Accession CP000057
Protein Accession YP_248615
Taxonomy ID 281310
Gene Starting Position 1030831
Gene Ending Position 1033233
Gene Strand (Orientation) -
Protein Name protective surface antigen D15
Protein pI 8.84
Protein Weight 81691.94
Protein Length 800
Protein Note Similar to: HI0917, D152_HAEIN
DNA Sequence 
>NC_007146.2:1030831-1033233 Haemophilus influenzae 86-028NP, complete genome
ATTAGAAAGAACCTCCAATACTAAATTGGAACTGTTCGACATCATCATTTTCATATTTTTTAATTGGTTT
GGCATAAGAGAATACCAATGGCCCAATAGGAGATTGCCATTGGAATCCGACACCTGTAGAGGCGCGAATA
CGGCTTGATTTGCCATAATCGGGTAAGCTTTTTAATACATTGTTATCTAACCCACTCTTATCCGATTTCC
ACTTAGTATTCCAAACACTTGCCGCATCAACAAATAGGGAAGTTCGGACCGTATTTTGGCTCTTATCGCT
CACAAACGGTGTTGGTACAATAAGTTCTGCACTCGCAGTTGTGATTGCATTACCACCAATCACATCAGAA
CTTATCTTATTAAAAGTACCATTACTATTACTATTACTATTACCATTTTGAGCGGCATAAATTGCGTTAG
GTCCAATACTACCATAAGCAAAACCACGTAATGAACCGATGCCACCCGCTGTATAAGTTTGATAGAACGG
TAAACGCTTGTTTCCAAAACCATTTGCATATCCTGCAGATGCTTTTGCAGATACAACCCAGAGGTGATCT
CTGTCTAATGGGTAGAAACCCTGTACATCTGCACTTAGTTTGTAGTATTTGTTATCAGAACCTGGAATAG
TAACTCGTCCACCAAGACTTGCTTTAACCCCTTTAGTTGGGAAATAGCCTCTATTAAGGCTGTTATAGTT
CCAACCAAAAGAAAAATCAAAGTCATTTGTTTTAATGCCATTACCTTTAAATTTCATTGATTGAATATAT
AAATTACGGTTATATTCTAGAGCAAAGTTACTAATTTTATTATAGGTATGGCCTAATCCTACATAATAGG
AGTTATTTTCATTTACAGGGAAACCTAAAGTAACATTACTTCCATAAGTCGTACGCTTATAGTTAGAGGA
TGTATCACTTTTAGAGTTATCGTAGTTTTCAAAGAAAACATTTCCACCAAGACTTACACCATCTTTAGTA
AAATAGGGCTCGGTATAACCCAAATTGACACTCGTACCATAATCATTTTTCGTACCAGCTATACTTACTG
CAGCCCCTGTTCCTAAGAAATTATCTTGTTTAACACTTGCTTGATAACTAATACCACTCTCTGTACCGTA
ACCAATACCAAAGTTGATACTACCCGTGTTACGTTCTTTGACTTTATATACGACATCCACTTCATCATTG
CTACCATTGATAGGATCAATTCGGTTTTCGACTGTTTCGAAGAAACCTGTACGATCTAAGCGAATTTTTC
CTAACTCAACTAATTGTGAATTATACCAAGTTCCTTCTTGTTGGCGCATTTCCTGACGTAAAGTGCTATC
AGCAGAAACGGTATTTCCTTCAAAGCGAAGTTGGCGAACAGTTAAACGTCGTCCAGCATCAACAACAAGG
GTTATCGCTAATGTTTTATTTGCATCATCAAAATCAGGTACTGAATTTACCGTTGCGCTACCGTAACCGC
GTTCTCCAAGTTTTGCTTTAATTGCATTTTCTACATCTGCAATATCACTACGGCGGAAAGTATCATTTAA
ATGTAATGCTGAAAGTAAAGGTTCAAGCTCGGCAGACATACCTCCCAGATTACCTATAATGCGTGCACTA
CGAAGGTCATACTGTAAACCTTCATTTACATCAATGGTTACATTAACTTTTGTTTTTTCATCATTTAGCT
GAACATCCGTTTTAGTAATTTGTGCTTTGGCATAGCCATTATTTAAATAATAATCACGAATTGACTGCAA
ATCTTTCTCGAATTGCGCACCTTCAAATTTATTTCCCCATAATTTCCACCAAGAATCAGGTTGTAATTCC
ATTTGTTCTTGTAATGTACTGCTACTAACAGATTCGTTCCCCTTGAAAGTTAATGATGCCAATTTTGCTT
TATCATCTTCATTGATTTGAATTAAAATTTCAGCGCGATTATTTGGTAGCGTATTGACAATAGGTTCAAC
GGTTGCGTTATAGCGACCTACACTTGCATAGTGTTCTTTTACACTTTTGGCAAATTCATTTAATTTTTCT
CGAATTAAAACATCGCCAACTTTAAACCCGTTAGCATCTAAGTTTTGTTTTAGTGCTTCAGTGGGAATAA
TAGAGTTACCTTTGATTTTAACATCTGAAATGATCGATTTAGCCACAACGCTAACAACAAGCACATCGCC
TTCTTGATGCGCTTTCACATCATCGAATCGACCACTTACGAATAAAGAGCGGACAATATTAGCCACATCA
TTGTCAGTCACACGCTGACCGGCACGAACAGGTAAACTTGCTCGGATTTGTTGTTTTAAGTCACCTTGAA
CACCATCCACACGAATATCTTTTGCCACAAAAGGTGCGGCAAACACAGTCGTTGTCGTACCGAATAATAA
ACTTGCGATTAGAAGTTTTTTCA
Protein Sequence 
>YP_248615.1 protective surface antigen D15 [Haemophilus influenzae 86-028NP]
MKKLLIASLLFGTTTTVFAAPFVAKDIRVDGVQGDLKQQIRASLPVRAGQRVTDNDVANIVRSLFVSGRF
DDVKAHQEGDVLVVSVVAKSIISDVKIKGNSIIPTEALKQNLDANGFKVGDVLIREKLNEFAKSVKEHYA
SVGRYNATVEPIVNTLPNNRAEILIQINEDDKAKLASLTFKGNESVSSSTLQEQMELQPDSWWKLWGNKF
EGAQFEKDLQSIRDYYLNNGYAKAQITKTDVQLNDEKTKVNVTIDVNEGLQYDLRSARIIGNLGGMSAEL
EPLLSALHLNDTFRRSDIADVENAIKAKLGERGYGSATVNSVPDFDDANKTLAITLVVDAGRRLTVRQLR
FEGNTVSADSTLRQEMRQQEGTWYNSQLVELGKIRLDRTGFFETVENRIDPINGSNDEVDVVYKVKERNT
GSINFGIGYGTESGISYQASVKQDNFLGTGAAVSIAGTKNDYGTSVNLGYTEPYFTKDGVSLGGNVFFEN
YDNSKSDTSSNYKRTTYGSNVTLGFPVNENNSYYVGLGHTYNKISNFALEYNRNLYIQSMKFKGNGIKTN
DFDFSFGWNYNSLNRGYFPTKGVKASLGGRVTIPGSDNKYYKLSADVQGFYPLDRDHLWVVSAKASAGYA
NGFGNKRLPFYQTYTAGGIGSLRGFAYGSIGPNAIYAAQNGNSNSNSNGTFNKISSDVIGGNAITTASAE
LIVPTPFVSDKSQNTVRTSLFVDAASVWNTKWKSDKSGLDNNVLKSLPDYGKSSRIRASTGVGFQWQSPI
GPLVFSYAKPIKKYENDDVEQFQFSIGGSF
Molecule Role Protective antigen
Molecule Role Annotation Purified rD15 was found to be highly immunogenic in mice, guinea pigs, and rabbits, and passive transfer of anti-rD15 antibodies protected infant rats from challenge with H. influenzae type b or type a in infant rat models of bacteremia (Loosmore et al., 1997).
Related Vaccines(s) H. influenzae D15 protein vaccine
References