• Vaccine Name: Newcastle Disease Virus HN Glycoprotein Subunit Vaccine
• Target Pathogen: Newcastle disease virus
• Target Disease: Newcastle disease
• Vaccine Ontology ID: VO_0011552
• Type: Subunit vaccine
• Status: Research
• Antigen: Hemagglutinin-neuraminidase (HN) glycoprotein (Lee et al., 2008).
• HN hemagglutinin-neuraminidase gene engineering:
  • Type: Recombinant protein preparation
  • Description:
  • Detailed Gene Information: Click Here.
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0001269
• Immunization Route: Intramuscular injection (i.m.)

Chicken Response

• Vaccination Protocol: For vaccination, chickens were inoculated intramuscularly with the Seppic-adjuvanted antigen (Lee et al., 2008).
• Challenge Protocol: Each group of vaccinated and unvaccinated chickens was challenged with the vvNDV Kr-005/00 strain through an intraocular inoculation with an 10^5.5 EID50 per bird. vvNDV Kr-005/00 was the representative strain of genotype VII, which is the dominant epizootic genotype in Korea. The chickens were kept under observation for 14 days after infection (Lee et al., 2008).
• Efficacy: A single dose of rNDHN(V) had a protective effect against mortality (p <0.01) in chickens (Lee et al., 2008).