• Vaccine Name: Dengue Vaccine using Vaccinia Virus expressing prM Protein
• Target Pathogen: Dengue Virus
• Target Disease: Dengue Fever
• Vaccine Ontology ID: VO_0011452
• Type: Recombinant vector vaccine
• Status: Research
• prM from Dengue virus 4 gene engineering:
  • Type: Recombinant vector construction
  • Description:
  • Detailed Gene Information: Click Here.
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: BALB/c mice were immunized by i .p .inoculation of 10^7 p .f .u . of recombinant vaccinia virus (Bray and Lai, 1991).
• Challenge Protocol: The mice were challenged at age 6 weeks by i .c challenge of 100 LD50 of D4 virus, then observed 21 days for signs of encephalitis or death (Bray and Lai, 1991).
• Efficacy: Mice immunized with the recombinant virus were protected against subsequent dengue 4 encephalitis challenge (Bray and Lai, 1991).