• Vaccine Name: C. immitis Subunit URE Protein Vaccine
• Target Pathogen: Coccidioides spp.
• Target Disease: Coccidioidomycosis (California disease, Desert rheumatism, San Joaquin valley fever, and Valley fev
• Vaccine Ontology ID: VO_0011463
• Type: Subunit vaccine
• Status: Research
• URE gene engineering:
  • Type: Recombinant protein preparation
  • Description:
  • Detailed Gene Information: Click Here.
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0001237
• Immunization Route: Subcutaneous injection

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: Mice each were immunized s.c. with recombinant protein (15 μg of rURE) or bovine serum albumin for control group (Li et al., 2001).
• Challenge Protocol: Mice were challenged by the i.p. route at 14 days after the last protein immunization or 30 days after the last DNA immunization. The inoculum contained 100 viable arthroconidia in 100 μl of PBS (Li et al., 2001).
• Efficacy: The rURE-immune mice showed significantly lower counts of C. immitis in both lungs and spleens compared to control mice immunized with BSA plus CpG ODN (Li et al., 2001).