• Vaccine Name: Pseudorabies Subunit gI Protein Vaccine
• Target Pathogen: Pseudorabies virus
• Target Disease: Aujeszky's disease
• Vaccine Ontology ID: VO_0004040
• Type: Subunit vaccine
• Status: Research
• GI gene engineering:
  • Type: Recombinant protein preparation
  • Description:
  • Detailed Gene Information: Click Here.
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Host Strain: C57BL/10
• Vaccination Protocol: For active immunization mice were injected i.m. (hind leg) with different concentrations of emulsified purified (by electroelution) fusion protein (Fuchs et al., 1990).
• Challenge Protocol: Twenty-four h later the animals were infected intramuscularly (i.m.) into a hind leg using 0-1 ml of a lethal dose ( > 100 LD50) of strain Phylaxia, and the mice were observed for at least 10 days (Fuchs et al., 1990).
• Efficacy: Vaccination of mice with fusion proteins containing the N terminus of gI from Suid herpesvirus 1 are able to confer protection to mice against a lethal challenge of PRV (Fuchs et al., 1990).