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Vaccine Detail
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MUC1 22mer Peptide Vaccines (APG, SAP) |
| Vaccine Information |
- Vaccine Name: MUC1 22mer Peptide Vaccines (APG, SAP)
- Target Pathogen: Cancer
- Target Disease: Cancer
- Type: Peptide vaccine
- Status: Research
- Host Species for Licensed Use: Mouse
- Antigen: MUC1 (Lakshminarayanan et al., 2016)
- Immunization Route: subcutaneous injection
- Description: A synthetic peptide vaccine containing long 22-amino acid non-glycosylated MUC1-derived peptides (APG 22mer: APGSTAPPAHGVTSAPDTRPAP; SAP 22mer: SAPDTRPAPGSTAPPAHGVT), adjuvanted with CpG 1826 oligonucleotide and Incomplete Freund's Adjuvant (IFA). The peptides are derived from the MUC1 tandem repeat (TR) region and contain both H-2Kb and H-2Db restricted epitopes. Vaccination generates increased CD4+ and CD8+ interferon-gamma producing T-cell responses with high avidity that recognize the long peptides as well as some embedded 9mer epitopes, and demonstrates intramolecular epitope spreading from the tandem repeat to cytoplasmic tail domains. In prophylactic settings, vaccination prior to B16.MUC1 tumor challenge provided 0% protection, while Panc02.MUC1 challenge showed delayed tumor onset. Therapeutic vaccination with SAP 22mer continued post-tumor challenge achieved 40% complete tumor eradication (4/10 mice) with significant tumor growth delay (p=0.001), whereas APG 22mer was therapeutically ineffective. MUC1 is a membrane-bound glycoprotein overexpressed in an aberrant or underglycosylated form in approximately 75% of lethal human cancers including breast, pancreatic, and ovarian cancers (Lakshminarayanan et al., 2016).
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| Host Response |
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| References |
Lakshminarayanan et al., 2016: Lakshminarayanan V, Supekar NT, Wei J, McCurry DB, Dueck AC, Kosiorek HE, Trivedi PP, Bradley JM, Madsen CS, Pathangey LB, Hoelzinger DB, Wolfert MA, Boons GJ, Cohen PA, Gendler SJ. MUC1 Vaccines, Comprised of Glycosylated or Non-Glycosylated Peptides or Tumor-Derived MUC1, Can Circumvent Immunoediting to Control Tumor Growth in MUC1 Transgenic Mice. PloS one. 2016; 11(1); e0145920. [PubMed: 26788922].
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