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Vaccine Detail
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B. abortus GAPDH DNA vaccine with IL-12 adjuvant |
| Vaccine Information |
- Vaccine Name: B. abortus GAPDH DNA vaccine with IL-12 adjuvant
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Type: DNA vaccine
- Status: Research
- Host Species for Licensed Use: Mouse
- Preparation: The B. abortus vaccine uses GAPDH with IL-12 adjuvant.(Rosinha et al., 2002b)
- Immunization Route: Intramuscular injection (i.m.)
- Description: In response to in-vitro stimulation by rGAPDH, splenocytes from mice vaccinated with rGAPDH or B. abortus S19 were able to produce gamma-interferon and tumour necrosis factor-a but not interleukin (IL)-4. Furthermore, the DNA vaccine partially protected mice against experimental infection.(Rosinha et al., 2002b)
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| Host Response |
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| References |
Rosinha et al., 2002b: Rosinha GM, Myioshi A, Azevedo V, Splitter GA, Oliveira SC. Molecular and immunological characterisation of recombinant Brucella abortus glyceraldehyde-3-phosphate-dehydrogenase, a T- and B-cell reactive protein that induces partial protection when co-administered with an interleukin-12-expressing plasmid in a DNA vaccine formulation. Journal of medical microbiology. 2002; 51(8); 661-671. [PubMed: 12171297].
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