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Vaccine Detail
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Bovine leukemia virus DNA vaccine encoding Env |
| Vaccine Information |
- Vaccine Name: Bovine leukemia virus DNA vaccine encoding Env
- Target Pathogen: Bovine Leukemia virus
- Vaccine Ontology ID: VO_0011378
- Type: DNA vaccine
- Status: Research
- Antigen: Bovine leukemia virus envelope gene encoding extracellular glycoprotein gp51and transmembrane glycoprotein gp30
- Env/Rex/Tax
gene engineering:
- Type: DNA vaccine construction
- Description: The bovine leukemia virus (BLV) envelope gene encoding extracellular glycoprotein gp51 (encoded by env gene) and transmembrane glycoprotein gp30 was cloned into a vehicle expression vector under the human cytomegalovirus (CMV) intermediate early promoter (Brillowska et al., 1999).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Cattle Response
- Efficacy: The intramuscular injection of this plasmid vector generated a cellular immune response. Seven out of ten cows vaccinated with the DNA construct resisted a drastic challenge (Brillowska et al., 1999).
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| References |
Brillowska et al., 1999: Brillowska A, Dabrowski S, Rułka J, Kubiś P, Buzała E, Kur J. Protection of cattle against bovine leukemia virus (BLV) infection could be attained by DNA vaccination. Acta biochimica Polonica. 1999; 46(4); 971-976. [PubMed: 10824867].
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