• Vaccine Name: Rabies vaccine rVac-N
• Target Pathogen: Rabies virus
• Target Disease: Rabies
• Vaccine Ontology ID: VO_0011555
• Type: Recombinant vector vaccine
• Status: Research
• RABVgp1 nucleoprotein N gene engineering:
  • Type: Recombinant vector construction
  • Description:
  • Detailed Gene Information: Click Here.
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Host Strain: A/J
• Vaccination Protocol: 4-week-old mice were injected intraperitoneally (i.p.) on days 0 and 14 with 10^7 p.f.u, of the recombinant viruses. Control mice received equal doses of vaccinia virus recombinant vSC8 that contained no rabies virus sequences (Fujii et al., 1994).
• Challenge Protocol: On day 21, the mice were challenged by footpad injection with 0.02 ml (20 MFPLDs0 , where MFPLDs0 represents mouse footpad 50% lethal dose) of the 1088 strain (Fujii et al., 1994).
• Efficacy: 92 % of mice given rVac-N (i.e. one animal succumbed b u t still had a prolonged lifespan) survived the challenge with rabies virus (Fujii et al., 1994).