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Vaccine Detail
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Infanrix |
| Vaccine Information |
- Vaccine Name: Infanrix
- Target Pathogen: Bordetella pertussis
- Target Disease: Whooping Cough
- Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed
- Tradename: Infanrix
- Manufacturer: GlaxoSmithKline Biologicals
- Vaccine Ontology ID: VO_0000064
- CDC CVX code: 20
- Type: Toxoid vaccine
- Status: Licensed
- Location Licensed: USA (License #1617 )
- Host Species for Licensed Use: Human
- Antigen: Diphtheria and tetanus toxoids and 3 pertussis antigens [inactivated pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertactin (69 kiloDalton outer membrane protein)] (FDA: Infanrix).
- Adjuvant:
- Preparation: Tetanus toxin is produced by growing Clostridium tetani in a modified Latham medium derived from bovine casein. The toxin is detoxified with formaldehyde, concentrated by ultrafiltration, and purified by precipitation, dialysis, and sterile filtration (FDA: Infanrix).
- Immunization Route: Intramuscular injection (i.m.)
- Storage: Store INFANRIX refrigerated between 2° and 8°C (36° and 46°F). Do not freeze.
- Approved Age for Licensed Use: INFANRIX is indicated for active immunization against diphtheria, tetanus, and pertussis (whooping cough) as a 5-dose series in infants and children 6 weeks to 7 years of age (prior to seventh birthday). INFANRIX should not be administered to any infant before the age of 6 weeks, or to individuals 7 years of age or older (FDA: Infanrix).
- Contraindication: Hypersensitivity to any component of the vaccine is a contraindication, the vaccine should not be administered to anyone with encephalopathy, progressive neurological disorders, or an allergic reaction to a previous dose (FDA: Infanrix).
- Description: The vaccine is an noninfectious, sterile combination of diphtheria and tetanus toxoids and 3 pertussis antigens [inactivated pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertactin (69 kiloDalton outer membrane protein)] adsorbed onto aluminum hydroxide (FDA: Infanrix).
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| Host Response |
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| References |
FDA: Infanrix: FDA: Infanrix [http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm101568.htm]
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