- Vaccine Name: Pediarix
- Target Pathogen: Bordetella pertussis
- Target Disease: Whooping Cough
- Product Name: Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B (Recombinant) and Inactivated Poliovirus Vaccine Combined
- Tradename: Pediarix
- Manufacturer: GlaxoSmithKline Biologicals
- Vaccine Ontology ID: VO_0000082
- CDC CVX code: 110
- Type: Toxoid vaccine
- Status: Licensed
- Location Licensed: United States
- Host Species for Licensed Use: Human
- Adjuvant:
- Allergen: yeast, neomycin,polymyxin B
- Preparation: The diphtheria toxin is produced by growing Corynebacterium diphtheriae in Fenton medium containing a bovine extract. The diphtheria, tetanus, and pertussis antigens are individually adsorbed onto aluminum hydroxide then diluted and combined to produce the final formulated vaccine (FDA: Pediarix).
- Immunization Route: Intramuscular injection (i.m.)
- Storage: The vaccine should be refrigerated between 2º and 8ºC (36º and 46ºF). Do not freeze.
- Approved Age for Licensed Use: PEDIARIX is indicated for active immunization against diphtheria, tetanus, pertussis (whooping cough), all known subtypes of hepatitis B virus, and poliomyelitis caused by poliovirus Types 1, 2, and 3 as a three-dose primary series in infants born of HBsAg-negative mothers, beginning as early as 6 weeks of age. PEDIARIX should not be administered to any infant before the age of 6 weeks, or to individuals 7 years of age or older.
- Contraindication: Hypersensitivity to any component of the vaccine, including yeast, neomycin, and polymyxin B, is a contraindication. The vaccine should also not be administered to anyone with a previous allergic reaction to a dose of the vaccine (FDA: Pediarix).
- Description: It contains diphtheria and tetanus toxoids, 3 pertussis antigens (inactivated pertussis toxin [PT] and formaldehyde-treated filamentous hemagglutinin [FHA] and pertactin [69 kiloDalton outer membrane protein]), hepatitis B surface antigen, plus poliovirus Type 1 (Mahoney), Type 2 (MEF-1), and Type 3 (Saukett) (FDA: Pediarix).
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