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Vaccine Detail

VAR2CSA

Vaccine Information

Vaccine Name: VAR2CSA
Target Pathogen: Plasmodium spp.
Target Disease: Malaria
Type: Subunit vaccine
Status: Research
Host Species for Licensed Use: None
Antigen: PfEMP1: mediate IE adhesion and facilitate parasite immunoevasion through antigenic variation. It is a large cysteine-rich transmembrane multidomain protein (~350 kDa) typically formed by six Duffy-binding-like domains with several interdomain regions. (Renn et al., 2021)
Immunization Route: Intramuscular injection (i.m.)
Description: VAR2CSA is the leading vaccine candidate to prevent placental malaria by using the VAR2CSA protein as the vaccine antigen and prevens sequesteration of P. falciparum-infected erythrocytes in placenal intervillous spaces.(Renn et al., 2021)

Host Response

References

Renn et al., 2021: Renn JP, Doritchamou JYA, Tentokam BCN, Morrison RD, Cowles MV, Burkhardt M, Ma R, Mahamar A, Attaher O, Diarra BS, Traore M, Dicko A, Tolia NH, Fried M, Duffy PE. Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinity. Communications biology. 2021; 4(1); 1309. [PubMed: 34799664].