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Vaccine Detail
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Pfs230D1-EPA/ AS01 |
| Vaccine Information |
- Vaccine Name: Pfs230D1-EPA/ AS01
- Target Pathogen: Plasmodium spp.
- Target Disease: Malaria
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: None
- Antigen: Pfs230 domain 1: Pre-fertilization antigens, expressed during gametocyte development in human (Duffy et al. 2021)
- Immunization Route: Intramuscular injection (i.m.)
- Description: The Pfs230D1-EPA/AS01 uses the Pfs230D1 pre-fertilization antigen conjugated with EPA nanoparticles with GSK platform AS01 as the vaccine adjuvant tested on mice.
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| Host Response |
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Mouse Response
- Host Strain: CD-1 Mice
- Immune Response: Pfs230D1-EPA induces higher titers and IgG levels in AS01 vs. alum adjuvants in mice (Rausch et al., 2023)
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| References |
Duffy et al. 2021: Study of the Transmission-Blocking Vaccine Pfs230D1-EPA/Matrix-M Against Malaria in Adults in Mali [https://clinicaltrials.gov/ct2/show/NCT05135273?term=vaccine&cond=Malaria%2CFalciparum&draw=2&rank=2]
Rausch et al., 2023: Rausch KM, Barnafo EK, Lambert LE, Muratova O, Gorres JP, Anderson C, Narum DL, Wu Y, Morrison RD, Zaidi I, Duffy PE. Preclinical evaluations of Pfs25-EPA and Pfs230D1-EPA in AS01 for a vaccine to reduce malaria transmission. iScience. 2023; 26(7); 107192. [PubMed: 37485364].
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