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Vaccine Detail
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Pfs230D1-EPA/ AS01 |
| Vaccine Information |
- Vaccine Name: Pfs230D1-EPA/ AS01
- Target Pathogen: Plasmodium spp.
- Target Disease: Malaria
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: None
- Antigen: Pfs230 domain 1: Pre-fertilization antigens, expressed during gametocyte development in human (Duffy et al. 2021)
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Adjuvant:
EPA: a recombinant, detoxified ExoProtein A from Pseudomonas aeruginosa (Talaat et al., 2016); AS01: AS01: a liposomal preparation that incorporates the Toll-like receptor 4 (TLR4) ligand 3-O-desacyl-4′-monophosphoryl lipid A (MPL) and the saponin fraction Quillaja saponaria 21 (QS-21) (Rausch et al., 2023)
- Immunization Route: Intramuscular injection (i.m.)
- Description: The Pfs230D1-EPA/AS01 uses the Pfs230D1 pre-fertilization antigen conjugated with EPA nanoparticles with GSK platform AS01 as the vaccine adjuvant tested on mice.
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| Host Response |
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Mouse Response
- Host Strain: CD-1 Mice
- Immune Response: Pfs230D1-EPA induces higher titers and IgG levels in AS01 vs. alum adjuvants in mice (Rausch et al., 2023)
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| References |
Duffy et al. 2021: Study of the Transmission-Blocking Vaccine Pfs230D1-EPA/Matrix-M Against Malaria in Adults in Mali [https://clinicaltrials.gov/ct2/show/NCT05135273?term=vaccine&cond=Malaria%2CFalciparum&draw=2&rank=2]
Rausch et al., 2023: Rausch KM, Barnafo EK, Lambert LE, Muratova O, Gorres JP, Anderson C, Narum DL, Wu Y, Morrison RD, Zaidi I, Duffy PE. Preclinical evaluations of Pfs25-EPA and Pfs230D1-EPA in AS01 for a vaccine to reduce malaria transmission. iScience. 2023; 26(7); 107192. [PubMed: 37485364].
Talaat et al., 2016: Talaat KR, Ellis RD, Hurd J, Hentrich A, Gabriel E, Hynes NA, Rausch KM, Zhu D, Muratova O, Herrera R, Anderson C, Jones D, Aebig J, Brockley S, MacDonald NJ, Wang X, Fay MP, Healy SA, Durbin AP, Narum DL, Wu Y, Duffy PE. Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults. PloS one. 2016; 11(10); e0163144. [PubMed: 27749907].
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