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Vaccine Detail
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Tumor Lysate-pulsed Dendritic Cell Vaccine |
| Vaccine Information |
- Vaccine Name: Tumor Lysate-pulsed Dendritic Cell Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0007740
- Type: whole cell cancer vaccine
- Status: Clinical trial
- Host Species for Licensed Use: None
- Immunization Route: Other
- Description: The vaccine is composed of dendritic cells pulsed with tumor cells lysates that stimulate a potent and specific cell mediated anti-tumor immune response. (NCIT_C1988) It can be used in combination with high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT). The combination may increase overall survival and progression-free survival for patients with high-risk pediatric and young adult tumors (localized solid tumors such as, sarcoma, neuroblastoma, and Wilms' tumor). (NCT00405327)
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| Host Response |
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| References |
NCIT_C1988: Dendritic Cell Tumor Cell Lysate Vaccine [https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C1988]
NCT00405327: A Pilot Study of Tumor Cell Vaccine for High-risk Solid Tumor Patients Following Stem Cell Transplantation [https://clinicaltrials.gov/study/NCT00405327]
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