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Vaccine Detail
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Multiple Signals loaded Dendritic Cells Vaccine |
| Vaccine Information |
- Vaccine Name: Multiple Signals loaded Dendritic Cells Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Type: whole cell cancer vaccine
- Status: Clinical trial
- Host Species for Licensed Use: None
- Antigen: HCC antigens (NCT04317248)
- Immunization Route: Intravenous injection (i.v.)
- Description: HBV-related hepatocellular carcinoma (HBV-HCC) carries highly heterogeneous antigens to facilitate cancer cells escaping from immune surveillance and constructs an immunosuppressive microenvironment. Multiple signals loaded dendritic cells vaccine can efficiently present T cells with antigens of HCC sensitize their antitumor properties meanwhile low dose cyclophosphamide (CY) can effectively improve the microenvironment of immunity. Multiple signals loaded dendritic cells vaccine combined low dose of cyclophosphamide combining with radical surgery or TACE or targeted agents for patients with hepatocellular carcinoma coul prolong their survival time. (NCT04317248)
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| Host Response |
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| References |
NCT04317248: "Cocktail" Therapy for Hepatitis B Related Hepatocellular Carcinoma [https://clinicaltrials.gov/study/NCT04317248]
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