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Vaccine Detail

KLH-pulsed autologous dendritic cell vaccine
Vaccine Information
  • Vaccine Name: KLH-pulsed autologous dendritic cell vaccine
  • Target Pathogen: Cancer
  • Target Disease: Cancer
  • Type: whole cell cancer vaccine
  • Status: Clinical trial
  • Host Species for Licensed Use: None
  • Antigen: KLH (NCT00868114)
  • Immunization Route: intratumoral
  • Description: Autologous dendritic cells are pulsed with KLH for this vaccination, combined with radiation or a gene therapy agent, TNFerade. TNFerade or radiation serves to generate cell death stimulating the immune response. The dendritic cell vaccine may direct a distant and lasting effective anti-tumor immune response to achieve a local and systemic clinical benefit. (NCT00868114)
Host Response
References
NCT00868114: Direct Tumor Injection KLH-Pulsed Dendritic Cells in Unresectable Pancreatic Cancer [https://clinicaltrials.gov/study/NCT00868114]