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Vaccine Detail
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Cyclin B1/WT-1/CEF-Loaded DC Vaccine |
| Vaccine Information |
- Vaccine Name: Cyclin B1/WT-1/CEF-Loaded DC Vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Type: whole cell cancer vaccine
- Status: Clinical trial
- Host Species for Licensed Use: None
- Antigen: cyclin B1/WT-1/CEF (NCT02018458)
- Immunization Route: subcutaneous injection
- Description: Patients with Locally Advanced, Triple-Negative Breast Cancer or ER-Positive, Her2-Negative Breast Cancer receive ex vivo-generated tumor antigen-loaded dendritic cells (DCs), which can prime lymphocytes and regulate and maintain immune responses. The vaccine may boost T cell immunity targeted against breast cancer, enhance chemotherapy effectiveness and decrease tumor metastagenicity, and decrease the recurrence rates of LA TNBC and ER+/HER2- BC. (NCT02018458)
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| Host Response |
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| References |
NCT02018458: Safety Study Of Chemotherapy Combined With Dendritic Cell Vaccine to Treat Breast Cancer [https://clinicaltrials.gov/study/NCT02018458]
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