VIOLIN: Vaccine Investigation and Online Information Network

Vaccine Detail

CPS2 (Capsule polysaccharide)

Vaccine Information

Vaccine Name: CPS2 (Capsule polysaccharide)
Target Pathogen: Klebsiella pneumoniae
Target Disease: Pneumonia, Bloodstream infections, Abscess
Type: Subunit vaccine
Status: Research
Host Species for Licensed Use: Macaque
Antigen: ST258 capsule polysaccharide type 2(CPS2) (Malachowa et al., 2019)
Preparation: CPS2 was extracted from K. pneumoniae NJST258_2 culture supernatant (Malachowa et al., 2019)
Immunization Route: Intramuscular injection (i.m.)

Host Response

References

Malachowa et al., 2019: Malachowa N, Kobayashi SD, Porter AR, Freedman B, Hanley PW, Lovaglio J, Saturday GA, Gardner DJ, Scott DP, Griffin A, Cordova K, Long D, Rosenke R, Sturdevant DE, Bruno D, Martens C, Kreiswirth BN, DeLeo FR. Vaccine Protection against Multidrug-Resistant Klebsiella pneumoniae in a Nonhuman Primate Model of Severe Lower Respiratory Tract Infection. mBio. 2019; 10(6); . [PubMed: 31848292].