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Vaccine Detail

K. pneumoniae polysaccharide-tetanus toxoid conjugate vaccine
Vaccine Information
  • Vaccine Name: K. pneumoniae polysaccharide-tetanus toxoid conjugate vaccine
  • Target Pathogen: Klebsiella pneumoniae
  • Target Disease: Pneumonia, Bloodstream infections, Abscess
  • Type: Conjugate vaccine
  • Status: Research
  • Host Species for Licensed Use: Rat
  • Antigen: The polysaccharide (PS) derived from K. pneumoniae NCTC 5055 lipopolysaccharide (LPS) (Chhibber et al., 2005)
  • Preparation: The polysaccharide (PS) derived from K. pneumoniae NCTC 5055 lipopolysaccharide (LPS) was covalently linked to tetanus toxoid by using carbodimide with adipic acid dihydrazide as a spacer molecule (Chhibber et al., 2005).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response
References
Chhibber et al., 2005: Chhibber S, Rani M, Vanashree Y. Immunoprotective potential of polysaccharide-tetanus toxoid conjugate in Klebsiella pneumoniae induced lobar pneumonia in rats. Indian journal of experimental biology. 2005; 43(1); 40-45. [PubMed: 15691064].