• Vaccine Name: Inactivated Influenza A virus (IIAV) with adjuvant 2F52
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Type: Inactivated or "killed" vaccine
• Status: Licensed
• Host Species for Licensed Use: Mouse
• Immunization Route: Intramuscular injection (i.m.)
• Description: "Inactivated influenza A virus (IIAV) in a murine lethal influenza virus challenge model, the lead compound 2F52 protects mice from a lethal infection" (Sato-Kaneko et al., 2021)

Mouse Response

• Immune Response: "2F52 [N-benzyl-N-(4-chloro-2,5-dimethoxyphenyl)-4-ethoxybenzenesulfonamide] modestly increased mitochondrial reactive oxygen species and induced the aggregation of MAVS... induced mtROS-mediated immune responses... activators of innate immunity via mitochondrial stress pathways... demonstrated protective effects in a murine lethal virus challenge study" (Sato-Kaneko et al., 2021)