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Vaccine Detail
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Dengue Virus Vaccine TV005 |
| Vaccine Information |
- Vaccine Name: Dengue Virus Vaccine TV005
- Target Pathogen: Dengue Virus
- Target Disease: Dengue Fever
- Type: Live, attenuated vaccine
- Status: Clinical trial
- Host Species for Licensed Use: None
- Host Species as Laboratory Animal Model: Human
- Antigen: Live attenuated tetravalent dengue vaccine TV005 composed of rDEN1Δ30, rDEN2/4Δ30, rDEN3Δ30/31, and rDEN4Δ30. (Hou et al., 2022)
- Preparation: TV005 is an admixture composed of 4 DENV strains attenuated by a 30-nucleotide deletion in the 3′ UTR (rDEN1Δ30 and rDEN4Δ30), one 30-nucleotide and one-31 nucleotide deletion in the 3′ UTR (rDEN3Δ30/31), or by replacing the prM and E of rDEN4Δ30 with those of DENV2 NGC (rDEN2/4Δ30). (Hou et al., 2022)
- Immunization Route: Intramuscular injection (i.m.)
- Description: Live attenuated tetravalent vaccine TV005 protects humans against DEN2Δ30 (Tonga/74) challenge. (Hou et al., 2022)
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