• Vaccine Name: MVA-BN-YF
• Target Pathogen: Yellow fever virus
• Target Disease: Yellow fever
• Type: Live, attenuated vaccine
• Status: Licensed
• Host Species for Licensed Use: Hamster
• Preparation: MVA-BN YF was prepared by inserting the coding region of preM and E that are based on the naturally occurring sequence of YFV into the MVA-BN backbone.(Julander et al., 2018)
• Immunization Route: Intramuscular injection (i.m.)
• Description: [A MVA-based YF vaccine was tested with and without a non-mineral oil adjuvant in a hamster model of lethal YF disease expressing the poly-protein PreM-E of YFV.(Julander et al., 2018)

Hamster Response

• Vaccination Protocol: Animals were vaccinated s.c. with 1 × 108 TCID50 of MVA-BN-YF, with or without Montanide adjuvant.(Julander et al., 2018)
• Immune Response: There were also significantly (p < 0.05) higher levels of nAb in the serum of animals vaccinated with MVA-BN YF with and without adjuvant when compared with those from animals vaccinated with YF-VAX(Julander et al., 2018)