• Vaccine Name: Ebola Virus Vaccine Ad5-ZGP
• Target Pathogen: Ebola virus
• Target Disease: Ebola hemorrhagic fever
• Type: Live, attenuated vaccine
• Status: Licensed
• Host Species for Licensed Use: Baboon
• Antigen: ZGP (Wong et al., 2015)
• ZGP gene engineering:
  • Type: Recombinant vector construction
  • Description: (Wong et al., 2015)
  • Detailed Gene Information: Click Here.
• Immunization Route: Intramuscular injection (i.m.)
• Description: An adenovirus vectored vaccine encoding Ebola virus ZGP providing protection in Macaque model. (Wong et al., 2015)

Macaque Response

• Vaccination Protocol: NHPs were treated at either 30 mins or 24 hrs after exposure. Control NHPs were treated with phosphate-buffered saline. Specific treatment procedures described in articles. (Wong et al., 2015)
• Immune Response: All surviving cynomolgus macaques treated 30 minutes or 24 hours after EBOV challenge had elevated anti-ZGP IgG levels by 14 days after infection, and levels remained elevated until the termination of the experiment 28 days after infection. ZGP-specific IgG was not detected in nonsurviving NHPs A4 and A8 but was detected in animal A3 by 7 days after infection. For nonsurviving and control animals in the 24-hour treatment groups, ZGP-specific IgG was not detected, with the exception of animal E2. Surviving animals in the 24-hour treatment groups developed elevated anti-ZGP IgG levels by 14 days after infection, which remained elevated 28 days after infection. (Wong et al., 2015)
• Challenge Protocol: NHPs were challenged with a uniformly lethal dose of 1000 plaque-forming units of EBOV (Ebola virus H.sapiens-tc/COD/1995/Kikwit-9510621; GenBank accession number AY354458). (Wong et al., 2015)
• Efficacy: Six of 9 NHPs (67%) survived the challenge when treated 30 minutes after exposure, whereas 1 of 4 (25%) survived challenge when treated 24 hours after infection. The 3 nonsurviving NHPs treated 30 minutes after challenge had a delayed time to death of 13, 11, and 13 days after infection, surviving nearly twice as long as the control animals, which died 7 days after infection. In contrast, the 3 nonsurviving cynomolgus macaques treated 24 hours after challenge died 7, 7, and 9 days after infection, which is similar to times of death for the control animals. Nonsurviving, treated rhesus macaques died 11 and 16 days after infection, which is longer than the control animals. (Wong et al., 2015)