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Vaccine Detail
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CCHF Virus VRP (Virus Replicon Particle) Vaccine |
| Vaccine Information |
- Vaccine Name: CCHF Virus VRP (Virus Replicon Particle) Vaccine
- Target Pathogen: Crimean-Congo Haemorrhagic Fever (CCHF)
- Type: Virus Replicon Particle Vaccine
- Status: Research
- Host Species for Licensed Use: None
- Antigen: S and L genome segments of IbAr10200 CCHF strain (Spengler et al., 2019)
- Preparation: The virus replicon particle (VRP) vaccine contains the complete S and L genome segments of the IbAr10200 strain, but lacks the M segment, restricting the VRP to a single round of replication. To optimize cell entry, VRPs are generated and amplified by co-transfecting a plasmid encoding the codon-optimized GPC of the Oman-98 strain. (Spengler et al., 2019)
- Immunization Route: subcutaneous injection
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| Host Response |
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