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Vaccine Detail
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T. cruzi DNA vaccine encoding trans-sialidase |
| Vaccine Information |
- Vaccine Name: T. cruzi DNA vaccine encoding trans-sialidase
- Target Pathogen: Trypanosoma cruzi
- Target Disease: Chagas disease
- Type: DNA vaccine
- Status: Research
- Host Species for Licensed Use: Mouse
- Antigen: trans-sialidase - In past studies, immunization of BALB/c mice with the TS gene elicited immune responses, as measured by antibody production and T-cell activation and had a significant reduction in peak parasitemia and survived lethal T. cruzi infection (Costa et al., 1998)
- Immunization Route: Intramuscular injection (i.m.)
- Description: T. cruzi DNA vaccine encoding the trans-sialidase gene intended to fight T. cruzi infection and induce an immune response (Rodrigues et al., 1999)
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| Host Response |
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| References |
Costa et al., 1998: Costa F, Franchin G, Pereira-Chioccola VL, Ribeirão M, Schenkman S, Rodrigues MM. Immunization with a plasmid DNA containing the gene of trans-sialidase reduces Trypanosoma cruzi infection in mice. Vaccine. 1998; 16(8); 768-774. [PubMed: 9627933].
Rodrigues et al., 1999: Rodrigues MM, Ribeirão M, Pereira-Chioccola V, Renia L, Costa F. Predominance of CD4 Th1 and CD8 Tc1 cells revealed by characterization of the cellular immune response generated by immunization with a DNA vaccine containing a Trypanosoma cruzi gene. Infection and immunity. 1999; 67(8); 3855-3863. [PubMed: 10417149].
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