|
|
Vaccine Detail
|
T. cruzi DNA vaccine encoding TSSA |
| Vaccine Information |
- Vaccine Name: T. cruzi DNA vaccine encoding TSSA
- Target Pathogen: Trypanosoma cruzi
- Target Disease: Chagas disease
- Type: DNA vaccine
- Status: Research
- Host Species for Licensed Use: Mouse
- Antigen: TSSA (Katae et al., 2002)
-
Adjuvant:
IL - 12 (Katae et al., 2002) - adjuvant that expands the CD8+ T cell population to control an infection and plays a significant role in the modulation of the CTL response (Gherardi et al., 2001)
- Immunization Route: Intramuscular injection (i.m.)
- Description: T. cruzi DNA vaccine encoding TSSA antigen enhanced by IL-12 adjuvant
|
| Host Response |
|
|
| References |
Gherardi et al., 2001: Gherardi MM, RamÃrez JC, Esteban M. Towards a new generation of vaccines: the cytokine IL-12 as an adjuvant to enhance cellular immune responses to pathogens during prime-booster vaccination regimens. Histology and histopathology. 2001; 16(2); 655-667. [PubMed: 11332721].
Katae et al., 2002: Katae M, Miyahira Y, Takeda K, Matsuda H, Yagita H, Okumura K, Takeuchi T, Kamiyama T, Ohwada A, Fukuchi Y, Aoki T. Coadministration of an interleukin-12 gene and a Trypanosoma cruzi gene improves vaccine efficacy. Infection and immunity. 2002; 70(9); 4833-4840. [PubMed: 12183527].
|
|
