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Vaccine Detail
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rPIV3-RSV-hMPV |
| Vaccine Information |
- Vaccine Name: rPIV3-RSV-hMPV
- Target Pathogen: Human Respiratory Syncytial Virus
- Target Disease: Respiratory tract disease
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Hamster
- F protein
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Hamster Response
- Vaccination Protocol: The hamsters were vaccinated intranasally with 106 PFU of b/h PIV3, b/h PIV3/RSV, RSV A2, b/h PIV3/hMPV, hMPV/NL/1/00, or placebo medium in a 100-μl volume, (Tang et al., 2003)
- Challenge Protocol: Animals were challenged intranasally with 106 PFU of RSV or hPIV3 per animal on day 28 postvaccination. (Tang et al., 2003)
- Efficacy: Animals immunized with b/h PIV3/RSV were protected completely from hPIV3 and RSV infection. (Tang et al., 2003)
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| References |
Tang et al., 2003: Tang RS, Schickli JH, MacPhail M, Fernandes F, Bicha L, Spaete J, Fouchier RA, Osterhaus AD, Spaete R, Haller AA. Effects of human metapneumovirus and respiratory syncytial virus antigen insertion in two 3' proximal genome positions of bovine/human parainfluenza virus type 3 on virus replication and immunogenicity. Journal of virology. 2003; 77(20); 10819-10828. [PubMed: 14512532].
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