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Vaccine Detail
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Ad5-RSV-F |
| Vaccine Information |
- Vaccine Name: Ad5-RSV-F
- Target Pathogen: Human Respiratory Syncytial Virus
- Target Disease: Respiratory tract disease
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: None
- Preparation: Adenovirus serotype 5-based RSV vaccine encoding the fusion (F) protein (Ad5.RSV-F)(Kim et al., 2014)
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Rat Response
- Vaccination Protocol: Animals were immunized intranasally (i.n.) and/or intramuscularly (i.m.) with Ad5.RSV-F (Kim et al., 2014)
- Challenge Protocol: (Kim et al., 2014)Post vaccination, animals were subsequently challenged with RSV/A/Tracy (i.n.)
- Efficacy: (Kim et al., 2014)The vaccine provided protective immunity against RSV challenge without enhanced lung disease in the rats
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| References |
Kim et al., 2014: Kim E, Okada K, Beeler JA, Crim RL, Piedra PA, Gilbert BE, Gambotto A. Development of an adenovirus-based respiratory syncytial virus vaccine: preclinical evaluation of efficacy, immunogenicity, and enhanced disease in a cotton rat model. Journal of virology. 2014; 88(9); 5100-5108. [PubMed: 24574396].
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