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Vaccine Detail
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Pfs48/45 in Matrix-M |
| Vaccine Information |
- Vaccine Name: Pfs48/45 in Matrix-M
- Target Pathogen: Plasmodium spp.
- Target Disease: Malaria
- Type: Subunit vaccine
- Status: Clinical trial
- Host Species for Licensed Use: Baboon
- Antigen: Pfs48/45(Minassian et al., 2022): plays an important role in the fertilization of plasmodium: males lacking Pfs48/45 show severely reduced fertility and are incapable of adhering to and penetrating female gametes. (Theisen et al., 2017)
- Pfs48/45
gene engineering:
- Type: Recombinant protein preparation
- Description: Pfs48/45 and the 10 C and 6 C fusion proteins. The secondary structure prediction of Pfs48/45 have assigned 2 loops in domain II between amino acid residues 190–210 and 239–259, and in domain III between the residues 302–327 and 357–397. Epitope I is located between residues 295 and 418. (Theisen et al., 2017)
- Detailed Gene Information: Click Here.
- Immunization Route: Intramuscular injection (i.m.)
- Description: Transmission Blocking Vaccine: induce antibodies that taken up by the mosquito and subsequently prevent development of parasites in the mosquito midgut (Theisen et al., 2017)
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