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Vaccine Detail
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Seasonal Influenza Vaccine -- "Virus-derived immunostinulatory" |
| Vaccine Information |
- Vaccine Name: Seasonal Influenza Vaccine -- "Virus-derived immunostinulatory"
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Type: Inactivated or "killed" vaccine
- Status: Research
- Host Species for Licensed Use: Mouse
- Antigen: influenza A virus
- Adjuvant:
- Preparation: no clear description of how vaccine was manufactured; "268nt DVG-derived oligonucleotide in syngery with Addavax or with inactivated influenza A virus"(Fisher et al., 2022)
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Immune Response: "DDO synergized with AddaVax and skewed the immune response towards type-1 immunity. The adjuvancy of DDO alone and in synergy with AddaVax was heavily dependent on type I interferon signaling... DDO induces robust antigen-specific Th1 and CD8 T-cell responses"
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| References |
Fisher et al., 2022: Fisher DG, Gnazzo V, Holthausen DJ, López CB. Non-standard viral genome-derived RNA activates TLR3 and type I IFN signaling to induce cDC1-dependent CD8+ T-cell responses during vaccination in mice. Vaccine. 2022; 40(50); 7270-7279. [PubMed: 36333225].
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